Protecting immunity to rotavirus (RV) is primarily mediated by antibodies produced by RV-specific memory B cells (RV-mBc). In order to evaluate the role of IgM+ RV-mBc in antiviral immunity, NOD/Shi-scid interleukin-2 receptor-deficient (IL-2Rnull) immunodeficient mice were adoptively transferred highly purified human IgM+ mBc and infected with virulent murine rotavirus. These mice LIFR developed high titers… Continue reading Protecting immunity to rotavirus (RV) is primarily mediated by antibodies produced